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Written By: Dr. Ahmad Saad, Health Content Writer
Medically Reviewed By: Dr. Gopal Grandhige, MD, FACS, Board-Certified Surgeon
Last Reviewed: May 25, 2026
PRP (platelet-rich plasma) and PRF (platelet-rich fibrin) are two of the leading non-surgical regenerative treatments for hair loss. Both work by using the patient’s own blood to deliver growth factors directly to the scalp, but they differ in preparation and how they stimulate regrowth. PRP isolates the plasma to produce a higher concentration of platelets, while PRF retains fibrin, a protein that acts as a natural scaffold to hold growth factors at the treatment site longer.
PRP and PRF are most effective for non-scarring types of hair loss, including androgenetic alopecia (male and female pattern hair loss), diffuse thinning, telogen effluvium, and certain cases of alopecia areata. Most treatment plans involve 3 to 6 sessions spaced several weeks apart, with visible improvements in shedding, texture, and density typically appearing over several months. Maintenance sessions every 6 to 12 months can help sustain results long term.
At Formation in Tampa, PRP and PRF hair treatments are administered by Jeff Atlas, PA-C, under the direction of Dr. Gopal Grandhige, a board-certified general surgeon specializing in aesthetic and regenerative medicine. Every treatment plan starts with a one-on-one consultation to evaluate hair loss type, scalp condition, and individual goals before recommending the right approach.
PRP and PRF take different paths to the same goal, and understanding those differences helps you make a more informed decision about your hair restoration plan.
The most obvious distinction is how each treatment is prepared. PRP is produced by isolating the plasma from red blood cells, resulting in a concentrated platelet solution. PRF, on the other hand, is derived from whole blood without that same level of separation.
Because PRP pulls only the plasma portion, it delivers a higher platelet concentration than PRF. That elevated platelet count can translate to a stronger initial stimulus for hair growth, making PRP a go-to option for many patients at Formation.
PRF brings its own advantage, though. It naturally contains fibrin, a protein that acts as a structural framework for new cell development. That built-in scaffold may give PRF an edge when it comes to supporting the formation of new hair follicles over time.
At Formation, Jeff Atlas, PA-C handles PRP and PRF injections directly. Jeff’s background in orthopaedics gives him hands-on experience with regenerative therapies, and he applies that same precision to every hair restoration treatment at our Tampa clinic.
PRP, or platelet-rich plasma, is a regenerative treatment that draws on the patient’s own blood to promote hair growth. The process begins with a small blood draw, which is then placed into a centrifuge to separate the red blood cells from the plasma. This concentrated plasma contains a high level of platelets and growth factors, which are injected directly into the scalp. Once delivered, these growth factors work to activate hair follicles and encourage stronger, more consistent hair production.
PRF, or platelet-rich fibrin, follows a similar concept to PRP but involves a distinct preparation method. Rather than isolating the plasma from red blood cells, the whole blood sample is placed into a specialized tube and processed through a centrifuge. The result is a gel-like matrix that combines both plasma and fibrin, which is then injected into the scalp. The fibrin acts as a natural scaffold, supporting the development of new cells and creating a favorable environment for hair follicle regeneration.
The best treatment for you comes down to your specific needs and goals. If you want a treatment with a high platelet concentration that actively stimulates hair growth, PRP may be the right fit. On the other hand, if you want a treatment that also supports new cell growth for longer-lasting results, PRF could be the stronger option.
Before starting any hair loss treatment, schedule a consultation with a qualified provider who can evaluate your situation. At Formation in Tampa, Jeff Atlas, PA-C brings years of hands-on experience from orthopaedics to every injection, giving patients a precise and informed approach to aesthetic treatments. He can help you determine which option aligns with your goals and walk you through what to expect from the process.
PRP and PRF can be effective options for many non-scarring types of alopecia. This includes androgenetic alopecia, both male and female pattern hair loss, diffuse thinning, telogen effluvium, and certain cases of alopecia areata. These treatments tend to work best when active hair follicles are still present in the treatment area.
The primary exception is scarring alopecia. When inflammation or scar tissue has permanently damaged the follicles, PRP or PRF may not be the most effective route. A thorough evaluation is essential before moving forward with any treatment plan.
At Formation, Jeff Atlas, PA-C can evaluate your scalp condition, hair loss pattern, medical history, and personal goals to determine whether PRP, PRF, KeraLase, or another approach is the right fit for you. For patients interested in complementary procedures, Formation also offers non-invasive contouring and body sculpting options.
Most PRP and PRF hair treatment plans involve a series of sessions spaced several weeks apart. A typical starting point is 3 to 6 sessions, though the exact number depends on the type of hair loss, scalp condition, the specific treatment chosen, and how well the hair responds over time.
Hair regrowth is a gradual process, so progress is typically evaluated over several months rather than after a single appointment. Many patients begin to notice changes such as less shedding, improved hair texture, stronger overall hair quality, and increased density. You can view real patient outcomes in our before and after gallery.
Once the initial course is complete, maintenance sessions may be recommended every 6 to 12 months to help sustain ongoing results.
PRP and PRF hair treatments work gradually by reinforcing the body’s natural hair growth cycle. Rather than producing immediate changes, visible improvements tend to unfold over several months following treatment.
After completing their initial series of sessions, many patients start to notice less shedding, better hair texture, stronger overall hair quality, or fuller density. Results can vary based on what’s causing the hair loss, how long thinning has been an issue, the current condition of the scalp, age, underlying medical factors, and how consistently treatments are maintained.
That’s why having a realistic treatment plan in place matters from the start. PRP and PRF are not overnight solutions, but for patients looking to strengthen hair density and improve hair quality over time, they can be a worthwhile part of a long-term approach.
Multiple clinical studies have demonstrated that PRP (Platelet Rich Plasma) delivers measurable results for individuals dealing with androgenetic alopecia (AGA), the condition commonly referred to as male or female pattern hair loss. Research consistently points to increases in both hair density and thickness, along with a noticeable reduction in ongoing hair shedding.
PRF (Platelet-Rich Fibrin) has also attracted attention as a potential treatment for hair loss, though the body of evidence remains more limited. One smaller-scale study suggested that PRF injections could support hair regrowth in AGA patients, but the findings did not reach statistical significance. Additional research is still needed to validate those early results.
At Formation, our team has extensive experience delivering regenerative treatments in a clinical setting built around patient safety and precision. PRP and PRF hair treatments are administered by Jeff Atlas, PA-C, a licensed physician assistant whose background in orthopaedics gives him a strong foundation in musculoskeletal anatomy and injection technique. Every patient starts with a one-on-one consultation so we can evaluate the type and stage of hair loss, current scalp condition, prior treatment history, and overall candidacy before building a personalized treatment plan. Formation also provides a full range of surgical and non-surgical procedures for patients looking to address other aesthetic goals alongside hair restoration.
The cost of PRP or PRF hair treatment can vary based on the treatment type, number of sessions, clinic location, and whether a treatment package is recommended. At Formation in Tampa, PRP and PRF treatments are typically priced per session or as a course, since hair regrowth treatment usually requires multiple sessions.
Side effects are generally mild and temporary when treatment is performed under proper clinical conditions. These may include scalp tenderness, redness, swelling, pinpoint bleeding, bruising, or a mild headache. More serious complications are rare, but any injectable treatment carries some degree of risk, including infection if sterile technique is not maintained.
Recovery is typically simple, with very little downtime. Most patients can return to their normal activities shortly after treatment, though your clinician may advise avoiding strenuous exercise, hot showers, direct sun exposure on the scalp, and harsh styling products for the first day or two. For patients considering additional procedures such as FaceTite or PDO thread lifts, our team can coordinate treatment timelines during your consultation.
PRP and PRF are both non-surgical treatment options that can help support natural hair regrowth in the right candidates. PRP is widely recognized for its high concentration of platelets and growth factors, while PRF provides the additional advantage of fibrin, which may keep growth factors active at the treatment site for a longer period.
The most effective treatment depends on the type of hair loss you’re experiencing, your current scalp condition, any previous treatments you’ve had, and your personal goals. A one-on-one consultation is the best starting point to determine whether PRP, PRF, or another hair restoration approach is the right fit for you.
Find out whether PRP or PRF could be the right solution for your type of hair loss. Schedule a consultation at Formation in Tampa to review your options with Dr. Gopal Grandhige, a board-certified general surgeon specializing in aesthetic and regenerative medicine. As an SSRP and ISSCA-certified clinic, Formation meets the highest standards for regenerative treatments including peptides, exosomes, and stem cells.
Both PRP and PRF offer non-surgical paths to supporting natural hair regrowth by using your body’s own healing properties. PRP delivers a higher platelet concentration for a stronger initial stimulus, while PRF includes fibrin that may hold growth factors at the treatment site longer. Most patients need 3 to 6 sessions to start seeing changes like reduced shedding, improved texture, and increased density.
Clinical studies back PRP’s effectiveness for androgenetic alopecia, and early research on PRF shows promise as well. Side effects are generally mild, recovery requires very little downtime, and maintenance sessions every 6 to 12 months can help sustain results over time.
If you’re ready to take the next step toward addressing your hair loss, schedule a consultation at Formation to find out which option aligns with your goals. Formation also offers a full range of HD liposuction, abdominoplasty, and 360 body lift procedures for patients looking to combine treatments under one roof.
PRP isolates plasma for a higher platelet concentration, while PRF retains fibrin to create a scaffold that may sustain growth factor release longer.
Both are effective for non-scarring types like androgenetic alopecia, diffuse thinning, telogen effluvium, and certain cases of alopecia areata.
Most plans start with 3 to 6 sessions spaced several weeks apart, with maintenance sessions recommended every 6 to 12 months.
Visible improvements typically begin to appear over several months, with patients noticing less shedding, better texture, and fuller density after completing their initial sessions.
Side effects are generally mild and temporary, including scalp tenderness, redness, swelling, pinpoint bleeding, or bruising.
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